This study was aimed at the effect of stress resilience in rats. The result showed that hydrogen molecules could be used as a new strategy to prevent the occurrence of stress-related diseases.

H2 can inhibit the growth, migration and invasion of cancer cells, and catalyze the apoptosis of cells. H2 induced A549 and H1975 remain in the g2/m phase of the cell cycle; In addition, H2 lowered NIBPL, SMC3, SMC5 and SMC6 expression ... All data showed that H2 can inhibit the progression of lung cancer and regulate SMC3, which provides a new method for the treatment of lung cancer.

Inhalation of high-concentrated H2 may inhibite the growth of non-small lung cancer, which mechanism is related with the inhibition of the expression of Ki-67, COX-2, VEGF

Further research is needed to investigate the mechanism by which high-concentration hydrogen exerts protective effects on SCI in vivo. High-concentration hyd

H2 inhibited cell viability, migration and invasion, and catalyzed cell apoptosis and H2 induced A549 and H1975 cells G2/M arrest. Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6. H2 translocated the subcellular location of SMC3 during cell division and decreased its stability and increased its ubiquitination in both A549 and H1975 cells. In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2. Animal experimental assay demonstrated that the tumor weight in H2 group was significantly smaller than that in control group, but was bigger than cis-platinum group. The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H2 or cis-platinum, especially for cis-platinum. All data suggested that H2 inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer.